|
KMID : 0613820100200081214
|
|
Journal of Life Science
2010 Volume.20 No. 8 p.1214 ~ p.1220
|
|
|
Characteristics and Antibiotic Susceptibility of Imipenem-Resistant Clinical Isolates Producing Carbapenemase
|
|
Choi Han-Na
Park Chul
Kim Hyung-Rag
Baik Keun-Sik
Kim Se-Na
Seong Chi-Nam
|
|
|
Abstract
|
|
|
|
Imipenem-resistant bacteria were isolated from clinical specimens taken from hospitalized patients in Suncheon, Korea. Fifty-four isolates were phylogenetically analyzed based on 16S rRNA gene and gyrB gene sequence comparisons. Isolates were affiliated with Pseudomonas aeruginosa (30 strains; 55.6%), Acinetobacter baumannii (21; 38.9%), Enterobacter hormaechei (2) and Pseudomonas putida (2). Twenty-two isolates produced metallo-β-lactamase (MBL); 12 Acinetobacter baumannii strains, 7 Pseudomonas aeruginosa strains, 2 P. putida strains and 1 Enterobacter hormaechei strain. Antibiotic susceptibility of the isolates was determined using the disc diffusion method and Vitek system. Strains producing metallo-β-lactamase (type IMP & VIM) were more resistant to antibiotics ceftazidime, aztreonam, amikacin and gentamicin than to strains producing OXA and SHV type of β-lactamase.
|
|
|
KEYWORD
|
|
|
Imipenem-resistant, 16S rRNA gene, Acinetobacter baumannii, metallo-β-lactamase, antibiotic susceptibility
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|